Accelerating Synthesis through Data Foundation and Structure to enable AI across Discovery and CMC

Dr David Nippa, Digital R&D Architect, Roche

ABSTRACT: This presentation explores how robust data foundations and digitalization are enabling AI applications to accelerate the transition from early drug discovery to CMC. Addressing the fundamental limitations of literature-trained AI (“success bias”), the talk introduces the Roche Reaction Database (DUCK) and the SURF data format as practical blueprints for capturing real-world laboratory execution—including critical failure data. By exposing departmental data biases between Discovery and Development, the presentation demonstrates how high-fidelity, machine-readable ecosystems enable contextual... Click here to Read More